gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Teclistamab crosslinks CD3 on T cells with BCMA on target cells, forming an immunologic synapse and triggering T cell cytotoxicity via perforin/granzyme release and cytokine-mediated killing of BCMA+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-cell antigen arm
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06353022
disease_id_num_tar_ref
5086
drug_id_num_tar_ref
13744