gene_symbol
PMEL
hgnc_id
HGNC:10880
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Tebentafusp binds gp100 peptide presented by HLA-A*02:01 on target cells and CD3 on T cells, recruiting and activating T cells to kill the bound cells via perforin/granzyme-mediated cytotoxicity (apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
peptide-HLA complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05785754
disease_id_num_tar_ref
5089
drug_id_num_tar_ref
13758