gene_symbol
IL3RA
hgnc_id
HGNC:6012
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD123 ADC binds IL3RA on target cells, is internalized, and releases a DNA-alkylating indolino-benzodiazepine payload via a cleavable linker, leading to DNA damage, S-phase arrest, and apoptosis of CD123-expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface receptor subunit targeted by ADC antibody
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06034470
disease_id_num_tar_ref
5095
drug_id_num_tar_ref
13773