gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Pivekimab sunirine targets CD123 on the cell surface; after internalization it releases a DNA‑alkylating payload that damages genomic DNA, causing S‑phase arrest and apoptosis in CD123‑overexpressing cells. DNA itself is not the targeted antigen.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Indolino-benzodiazepine (IGN) payload covalent DNA alkylation
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06034470
disease_id_num_tar_ref
5095
drug_id_num_tar_ref
13773