gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
RC48 targets HER2, is internalized, and releases MMAE that inhibits beta-tubulin to disrupt microtubules and kill HER2+ cells; beta-tubulin expression alone is not targeted, though bystander killing may occur.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload MMAE binds the vinca site to inhibit polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06730373
disease_id_num_tar_ref
5100
drug_id_num_tar_ref
13794