gene_symbol
TNFRSF17
hgnc_id
HGNC:11913
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR-T cells recognize BCMA on target cells and, upon engagement, activate and kill via perforin/granzyme-mediated cytolysis (and Fas/FasL apoptosis).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Membrane-bound BCMA on malignant plasma cells (cell-surface TNFRSF17).
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05850286
disease_id_num_tar_ref
5102
drug_id_num_tar_ref
13809