gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind GPRC5D on target cells, activating CAR signaling and T‑cell cytolysis via perforin/granzyme (and death‑receptor) pathways, killing the GPRC5D+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface GPCR on malignant plasma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06298266
disease_id_num_tar_ref
441
drug_id_num_tar_ref
1242