gene_symbol
FAS
hgnc_id
HGNC:11920
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CAR engagement activates NK cells, which express FasL that binds FAS (CD95) on target cells to trigger death‑receptor (caspase-mediated) apoptosis; perforin/granzyme may also contribute.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Death-receptor pathway engagement via FAS ligand (FASLG) from NK/CAR-NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06572956
disease_id_num_tar_ref
5107
drug_id_num_tar_ref
13828