gene_symbol
TNFRSF10A
hgnc_id
HGNC:11904
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Upon CAR engagement with their specific antigen (not DR4), CAR‑NK cells kill via death‑receptor pathways; NK‑expressed TRAIL binds TRAIL‑R1 (DR4) on target cells, triggering extrinsic apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by TRAIL (TNFSF10) expressed by NK/CAR-NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06572956
disease_id_num_tar_ref
5107
drug_id_num_tar_ref
13828