gene_symbol
TNFRSF10B
hgnc_id
HGNC:11905
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Activated CAR-NK cells express TRAIL that binds DR5 (TRAIL-R2) on target cells, triggering death-receptor (extrinsic) apoptosis via caspase-8; NK cells may also kill via perforin/granzyme.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Engaged by TRAIL (TNFSF10) expressed by NK/CAR-NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06572956
disease_id_num_tar_ref
5107
drug_id_num_tar_ref
13828