gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR T cells bind CD19 via the tandem scFv, become activated through CD3ΞΆ/4-1BB signaling, and kill target cells via perforin/granzyme-mediated lysis and death-receptor pathways.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
tandem scFv target within bispecific CAR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06735495
disease_id_num_tar_ref
5110
drug_id_num_tar_ref
13839