gene_symbol
FOLR1
hgnc_id
HGNC:3791
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
ADC binds FRĪ± on tumor cells, is internalized, cleavable linker releases exatecan (topoisomerase I inhibitor) causing DNA strand breaks, cell-cycle arrest, and apoptosis; with potential bystander killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface GPI-anchored tumor-associated antigen
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06400472
disease_id_num_tar_ref
5118
drug_id_num_tar_ref
13865