gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the EBV peptide–HLA class I complex on tumor cells and kill them via CTL effector mechanisms (perforin/granzyme release and Fas–FasL–mediated apoptosis), with cytokine auto-secretion enhancing function and persistence.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–HLA class I complex recognized by the engineered TCR; exact EBV epitope and HLA allele not specified
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT04509726
disease_id_num_tar_ref
5121
drug_id_num_tar_ref
13878