gene_symbol
TNFRSF8
hgnc_id
HGNC:11923
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti-CD30 ADC binds CD30, is internalized, and releases MMAE via proteolytic linker cleavage; MMAE disrupts microtubules, causing G2/M arrest and apoptosis of CD30-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
cell-surface receptor (TNF receptor superfamily member 8)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06377566
disease_id_num_tar_ref
444
drug_id_num_tar_ref
1250