gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Avelumab binds PD-L1 on target cells; its Fc engages CD16a (FcγRIIIa) on NK cells to trigger ADCC against PD-L1-expressing cells. CD16a-expressing cells serve as effectors and are not killed by the drug.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc-dependent engagement mediating ADCC on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05699135
disease_id_num_tar_ref
5137
drug_id_num_tar_ref
13924