gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The ADC binds HER2, is internalized, and releases the DXd topoisomerase I inhibitor payload, causing DNA damage and apoptosis in HER2+ cells; it can also mediate ADCC and bystander killing.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Trastuzumab component binds extracellular domain (domain IV) of HER2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06630130
disease_id_num_tar_ref
5138
drug_id_num_tar_ref
13925