gene_symbol
TUBB
hgnc_id
HGNC:20778
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Brentuximab vedotin targets CD30 on the cell surface; after internalization, MMAE is released and inhibits β‑tubulin polymerization, causing mitotic arrest and apoptosis. β‑tubulin expression alone does not lead to selective killing without CD30.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
vinca site binding by MMAE (microtubule polymerization inhibitor)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06377566
disease_id_num_tar_ref
444
drug_id_num_tar_ref
1250