gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Neoantigen-specific TCRs recognize the patient-specific peptide–HLA class I complex on tumor cells, triggering cytotoxic T lymphocyte killing via perforin/granzyme (and Fas–FasL)–mediated apoptosis.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-A/B/C restricted; recognized by CD8+ TCR; peptide–MHC complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06431529
disease_id_num_tar_ref
5155
drug_id_num_tar_ref
13969