gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Infused neoantigen-specific T cells use endogenous TCRs to recognize the neoantigen–HLA class II complex on target cells and kill them via perforin/granzyme-mediated cytolysis (and Fas–FasL), inducing apoptosis.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
HLA-DR/DP/DQ restricted; recognized by CD4+ TCR; peptide–MHC complex
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06431529
disease_id_num_tar_ref
5155
drug_id_num_tar_ref
13969