gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Obinutuzumab binds CD20 on B cells; its Fc engages FcγRIIIa to trigger NK cell–mediated ADCC (and phagocytosis) and also induces direct, caspase-independent cell death; some complement-mediated lysis may occur.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Type II epitope on extracellular domain; glycoengineered Fc enhances FcγRIIIa engagement for ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05627557
disease_id_num_tar_ref
5159
drug_id_num_tar_ref
13977