gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
HS-20093 targets B7-H3, not DNA topoisomerase. After B7-H3 binding and internalization, it releases a topoisomerase inhibitor that blocks DNA replication and induces apoptosis (with possible Fc-mediated ADCC/CDC).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
ADC payload (topoisomerase inhibitor) target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06332170
disease_id_num_tar_ref
5160
drug_id_num_tar_ref
13983