gene_symbol
TOP1
hgnc_id
HGNC:11986
binding_type
other
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
After the ADC binds B7-H3 and releases the DXd payload, DXd inhibits DNA topoisomerase I in exposed cells, causing DNA damage and apoptosis (including bystander killing).
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
DXd payload target enzyme
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06330064
disease_id_num_tar_ref
44
drug_id_num_tar_ref
111