gene_symbol
CD274
hgnc_id
HGNC:17635
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Avelumab’s IgG1 Fc engages Fc receptors on NK cells to mediate antibody-dependent cellular cytotoxicity (ADCC) against PD-L1–expressing cells; it also indirectly enhances T-cell killing by blocking PD-1/PD-L1 signaling.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Blocks PD-L1 interactions with PD-1 and CD80; Fc region can engage Fc-gamma receptors (e.g., CD16a) to mediate ADCC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05878964
disease_id_num_tar_ref
5162
drug_id_num_tar_ref
13996