gene_symbol
CLDN18
hgnc_id
HGNC:2039
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Binding to CLDN18.2 localizes CD47 blockade on tumor cells, enabling Fcγ receptor–mediated engagement of macrophages and release of the CD47–SIRPα checkpoint, leading to antibody-dependent cellular phagocytosis (ADCP) of CLDN18.2-positive cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
Tumor-selective splice isoform of claudin-18 expressed on gastric/GEJ, PDAC, and BTC tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05482893
disease_id_num_tar_ref
5170
drug_id_num_tar_ref
14018