gene_symbol
CD47
hgnc_id
HGNC:1682
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The antibody localizes CD47 blockade to CLDN18.2+ tumor cells, removing the CD47–SIRPα “don’t‑eat‑me” signal and enabling macrophage phagocytosis of CLDN18.2+ tumor cells; CD47 expression alone is not sufficient for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Myeloid checkpoint target; blockade localized via co-engagement with CLDN18.2
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05482893
disease_id_num_tar_ref
5170
drug_id_num_tar_ref
14018