gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The ADC targets B7-H3 on the cell surface, is internalized, and releases a topoisomerase-inhibiting payload that blocks DNA replication and induces apoptosis; Fc-mediated ADCC/ADCP may contribute. DNA topoisomerase expression itself is not the targeting determinant.
enzyme_product
On
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Target of the released topoisomerase inhibitor payload
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06001255
disease_id_num_tar_ref
5171
drug_id_num_tar_ref
14028