gene_symbol
MS4A1
hgnc_id
HGNC:7315
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Rituximab binds CD20 on B cells and kills them via Fc-mediated ADCC by NK cells/macrophages, complement-dependent cytotoxicity, and apoptosis upon CD20 cross-linking.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
B-cell surface protein; rituximab binds a conformational epitope on the large extracellular loop
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06006117
disease_id_num_tar_ref
5177
drug_id_num_tar_ref
14043