gene_symbol
FAP
hgnc_id
HGNC:3590
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Radiolabeled FAP inhibitor binds FAP on cancer-associated fibroblasts, is internalized, and 177Lu beta emissions induce DNA double-strand breaks, leading to cell death; cross-fire can also affect nearby cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Expressed on cancer-associated fibroblasts (CAFs)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05723640
disease_id_num_tar_ref
5182
drug_id_num_tar_ref
14059