gene_symbol
BCL2
hgnc_id
HGNC:990
binding_type
other
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Venetoclax inhibits BCL-2 in BCL-2–dependent cells, enabling BAX/BAK activation and mitochondrial outer membrane permeabilization, leading to caspase-mediated apoptosis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds the BH3-binding hydrophobic groove to inhibit anti-apoptotic function
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06078306
disease_id_num_tar_ref
5183
drug_id_num_tar_ref
14061