gene_symbol
CD19
hgnc_id
HGNC:1633
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CD19 CAR T cells bind CD19 on target B cells, triggering CD3ΞΆ/co-stimulatory signaling and forming a cytotoxic synapse that kills CD19+ cells via perforin/granzyme-mediated apoptosis (and Fas/FasL pathways).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface B-cell lineage marker; HLA-independent CAR binding
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05665725
disease_id_num_tar_ref
5187
drug_id_num_tar_ref
14068