gene_symbol
BTN3A1
hgnc_id
HGNC:1138
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Vγ9Vδ2 T cells sense phosphoantigen-induced BTN3A1/BTN2A1 on target cells via their TCR, triggering activation and perforin/granzyme-mediated cytolysis (with NKG2D co-stimulation).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
PAg-dependent activation; cooperates with BTN2A1 to engage Vγ9Vδ2 TCR
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06396481
disease_id_num_tar_ref
446
drug_id_num_tar_ref
1260