gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
AFM28 binds CD16A on NK/macrophages to engage them against CD123+ tumor cells, triggering NK-cell ADCC that kills the CD123+ targets; CD16A-expressing effector cells are not killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Fc receptor on NK cells and macrophages
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05817058
disease_id_num_tar_ref
5192
drug_id_num_tar_ref
14077