gene_symbol
AFP
hgnc_id
HGNC:317
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the AFP peptide presented by HLA-A*02:03 and directly induce MHC-restricted killing of target cells via perforin/granzyme-mediated apoptosis (with contributions from Fas–FasL and cytokines).
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
On
gated
Off
other_modifier
MHC class I restricted; HLA-A*02:03
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06515314
disease_id_num_tar_ref
5193
drug_id_num_tar_ref
14078