gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR-T cells recognize the KRAS G12D peptide presented by HLA-C*08:02 on tumor cells and directly induce CTL-mediated killing via perforin/granzyme and Fas–FasL apoptosis.
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Peptide–MHC (pMHC) complex recognized by TCR; epitope derived from KRAS G12D presented by HLA-C*08:02
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06218914
disease_id_num_tar_ref
5195
drug_id_num_tar_ref
14085