gene_symbol
BTN2A1
hgnc_id
HGNC:1136
binding_type
receptor ligand recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Vγ9Vδ2 T cells recognize phosphoantigen-induced BTN2A1/BTN3A1 on target cells via their TCR, activating perforin/granzyme-mediated cytotoxicity (with cytokine release).
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
On
other_modifier
Co-ligand for Vγ9 chain; works with BTN3A1 during phosphoantigen sensing
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06396481
disease_id_num_tar_ref
446
drug_id_num_tar_ref
1260