gene_symbol
KRAS
hgnc_id
HGNC:6407
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Engineered TCR T cells recognize the KRAS G12D–HLA-A*11:02 complex and directly lyse target cells via TCR activation leading to perforin/granzyme-mediated apoptosis (with supportive cytokine effects).
enzyme_product
On
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
KRAS G12D neoantigen presented by HLA class I (HLA-A*11:02)
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06218914
disease_id_num_tar_ref
5195
drug_id_num_tar_ref
14086