gene_symbol
UNKNOWN
binding_type
other
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Belantamab mafodotin binds BCMA on target cells, is internalized, and releases MMAF to inhibit tubulin and disrupt microtubules, inducing apoptosis; Fc effector functions add ADCC/ADCP. Cells are not killed simply for expressing tubulin.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Payload target of MMAF; inhibits microtubule polymerization
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06413511
disease_id_num_tar_ref
5212
drug_id_num_tar_ref
14135