gene_symbol
FCGR3A
hgnc_id
HGNC:3619
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
CD16 is on NK effector cells; the TriKE uses CD16 to engage and IL-15 to activate/expand NK cells, which then kill CD33+ target myeloid cells via NK-mediated cytotoxicity (perforin/granzyme), not CD16+ cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
On
hla_specific
Off
gated
Off
other_modifier
NK cell Fc receptor; CD16A isoform
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06594445
disease_id_num_tar_ref
5214
drug_id_num_tar_ref
14138