gene_symbol
CD33
hgnc_id
HGNC:1659
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
TriKE bridges NK cells (via CD16) to CD33+ target cells, forming an immune synapse that triggers NK degranulation (perforin/granzymes) and killing; the IL-15 moiety activates/expands NK cells via JAK/STAT to enhance sustained cytotoxicity.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Myeloid lineage antigen on leukemic blasts and MDSCs
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06594445
disease_id_num_tar_ref
5214
drug_id_num_tar_ref
14138