gene_symbol
IL2RB
hgnc_id
HGNC:6009
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The IL-15 moiety engages CD122 on NK cells to activate and expand them; the drug bridges NK cells (via CD16) to CD33+ targets for NK-mediated cytotoxicity. CD122-expressing cells themselves are not targeted or killed.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IL-15 receptor signaling subunit engaged by IL-15 moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06594445
disease_id_num_tar_ref
5214
drug_id_num_tar_ref
14138