gene_symbol
IL2RG
hgnc_id
HGNC:6010
binding_type
receptor ligand recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The IL-15 moiety engages the IL-2/15 receptor beta/gamma (CD122/CD132) on NK cells to activate and expand them via JAK/STAT; activated NK cells then kill CD33+ targets when bridged by the anti-CD16 and anti-CD33 domains. CD132-expressing cells are not the lytic targets.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
IL-15 receptor signaling subunit engaged by IL-15 moiety
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06594445
disease_id_num_tar_ref
5214
drug_id_num_tar_ref
14138