gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
CAR recognition of GPRC5D activates the engineered T cells via CD3ζ/costimulatory signaling, triggering perforin/granzyme (and Fas–FasL)–mediated killing of GPRC5D-expressing cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
surface antigen on malignant plasma cells; bispecific CAR target
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05998928
disease_id_num_tar_ref
5221
drug_id_num_tar_ref
14174