gene_symbol
SLAMF7
hgnc_id
HGNC:21394
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Elotuzumab binds SLAMF7 on myeloma cells and its Fc engages Fcγ receptors on NK cells to trigger antibody-dependent cellular cytotoxicity (ADCC); it also activates NK cells via SLAMF7, enhancing lysis of SLAMF7+ target cells.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Highly expressed on multiple myeloma cells; also present on NK cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05560399
disease_id_num_tar_ref
5226
drug_id_num_tar_ref
14181