gene_symbol
CLDN1
hgnc_id
HGNC:2032
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Anti-CLDN1 mAb binds non-junctional CLDN1 on tumor cells and, via its Fc region, recruits FcγR+ immune effectors to mediate ADCC (e.g., NK cell–mediated lysis) of CLDN1-positive cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds an exposed extracellular loop epitope on non-junctional CLDN1 on tumor cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06054477
disease_id_num_tar_ref
5236
drug_id_num_tar_ref
14219