gene_symbol
GPRC5D
hgnc_id
HGNC:13310
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Talquetamab bridges CD3 on T cells to GPRC5D on target cells, activating T cells to kill GPRC5D-expressing cells via perforin/granzyme-mediated cytolysis.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Tumor-associated antigen overexpressed on multiple myeloma cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06577025
disease_id_num_tar_ref
5238
drug_id_num_tar_ref
14229