gene_symbol
CD3E
hgnc_id
HGNC:1674
binding_type
antigen recognition
cytotoxicity
NO
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
Talquetamab binds CD3 on T cells and GPRC5D on myeloma cells to crosslink and activate T cells, which kill GPRC5D+ tumor cells via perforin/granzyme; CD3+ T cells are not targeted for killing.
enzyme_product
Off
epitope
Off
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Epsilon chain of the TCR-CD3 complex on T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06577025
disease_id_num_tar_ref
5238
drug_id_num_tar_ref
14229