gene_symbol
ERBB2
hgnc_id
HGNC:3430
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
Fc-mediated ADCC via FcγR-expressing immune cells (e.g., NK cells) against HER2+ cells; may also contribute via CDC and apoptosis from HER2 signaling blockade.
enzyme_product
On
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Binds extracellular domain (ECD) subdomain IV; blocks dimerization/signaling and mediates ADCC via Fc engagement
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT05982301
disease_id_num_tar_ref
5242
drug_id_num_tar_ref
14250