gene_symbol
CD276
hgnc_id
HGNC:19137
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
DIRECT
cytotoxicity_mechanism
The anti–B7-H3 ADC binds CD276 on target cells, is internalized, and releases a topoisomerase inhibitor payload that blocks DNA topoisomerase activity, causing replication arrest, DNA damage, and apoptosis of B7-H3–expressing cells.
enzyme_product
Off
epitope
On
variant
Off
isoform
Off
hla_specific
Off
gated
Off
other_modifier
Cell-surface immune checkpoint ligand targeted by the antibody component of the ADC
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06052423
disease_id_num_tar_ref
5246
drug_id_num_tar_ref
14260