gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA vaccine primes neoantigen-specific CD8+ T cells that recognize the MHC I–presented neoantigen peptides on tumor cells and kill them via perforin/granzyme release and Fas–FasL pathways, with CD4+ T-cell help.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Individualized set (up to ~20 per patient) presented by HLA-A/-B/-C to CD8+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06077760
disease_id_num_tar_ref
5249
drug_id_num_tar_ref
14265