gene_symbol
UNKNOWN
binding_type
antigen recognition
cytotoxicity
YES
cytotoxicity_type
INDIRECT
cytotoxicity_mechanism
The mRNA vaccine primes neoantigen-specific T cells; CD8+ CTLs (and CD4+ CTLs if tumors present the peptide on MHC II) recognize the neoantigen–MHC complexes on cancer cells and kill them via perforin/granzyme-mediated cytolysis.
enzyme_product
Off
epitope
On
variant
On
isoform
Off
hla_specific
On
gated
Off
other_modifier
Individualized set (up to ~20 per patient) presented by HLA-DR/-DP/-DQ to CD4+ T cells
trial_id_tar_ref
drug_id_tar_ref
disease_id_tar_ref
nct_id_tar_ref
NCT06077760
disease_id_num_tar_ref
5249
drug_id_num_tar_ref
14265